Gram negative aerobic coccobacillus
3 species responsible for human infection:
- B. Abortus (disease of cattle) – Africa and india
- B. melitensis (disease of sheep, goats and camels) – Mediterranean middle east and central & south America.
- B. Suis (disease of pigs) - still problem in USA
Incubation: 1 week to several months
Organisms ingested or inhaled and taken up into the reticuloendotheial system.
Sources: unpasteurised dairy products, contaminated meat, placentae or infected animals
People that work with animals like Farmers and vets are at risk
Frequency is highest in agricultural societies
Middle east and southern Europe are high risk areas.
Brucella bacteria survive intracellularly by avoiding the immune system in several ways:
- Poor inducers of inflammatory cytokines (ie TNF/interferon)
- Don’t activate the complement system
- Inhibit programmed cell death
Following replication the bacteria are released and cause cell lysis. This can lead to systemic disease and can involve almost every organ system.
Usually self limiting over 2-3 weeks
Rarely fatal unless complicated by endocarditis
Relapse may occur, and symptoms may continue for years
Blood or bone marrow or clean catch urine or CSF cultures
May also see:
- Abnormal LFTs
Long course of doxycycline + rifampicin/gentamicin
Hygiene whilst handling animals
Vaccination available for cattle but not humans