Haematopoiesis – Blood Cell Formation

Introduction All blood cells develop from haemocytoblasts The process is called haematopoiesis (sometimes just haemopoiesis) Haemocytoblasts are also known as pluripotential stem cells. These cells can replicate themselves as well as differentiate into other...

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Haemophilia A

X-linked recessive condition, deficiency of factor VIII, prevalence 1 in 10,000 Range of possible mutations, 30% of cases due to sporadic mutation Low factor VIII levels predispose to bleeding – risk proportional to factor...

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Haemophilia B (Christmas Disease)

X-linked recessive condition, deficiency of factor IX Severely affected patients develop haemarthroses Inhibitors (factor IX antibodies) less common Recombinant factor IX – 18 hour half life so daily dosing to maintain levels Prophylactic treatment...

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