Haemophilia A

X-linked recessive condition, deficiency of factor VIII, prevalence 1 in 10,000 Range of possible mutations, 30% of cases due to sporadic mutation Low factor VIII levels predispose to bleeding – risk proportional to factor...

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Haemophilia B (Christmas Disease)

X-linked recessive condition, deficiency of factor IX Severely affected patients develop haemarthroses Inhibitors (factor IX antibodies) less common Recombinant factor IX – 18 hour half life so daily dosing to maintain levels Prophylactic treatment...

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