Haematopoiesis – Blood Cell Formation

Introduction All blood cells develop from haemocytoblasts The process is called haematopoiesis (sometimes just haemopoiesis) Haemocytoblasts are also known as pluripotential stem cells. These cells can replicate themselves as well as differentiate into other...

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Haematuria

Introduction Haematuria is the passing of blood in the urine Frank Haematuriais the presence of blood on macroscopic investigation (i.e. looking at the blood) Microscopic Haematuria – is where you can only see RBC’s...

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Haemochromatosis

Introduction The term haemochromatosis is usually used to describe a group of autosomal recessive disorders of iron metabolism. It is sometime called hereditary haemochromatosis and abbreviated to HHC. The most common mutations are in...

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Haemophilia A

X-linked recessive condition, deficiency of factor VIII, prevalence 1 in 10,000 Range of possible mutations, 30% of cases due to sporadic mutation Low factor VIII levels predispose to bleeding – risk proportional to factor...

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Haemophilia B (Christmas Disease)

X-linked recessive condition, deficiency of factor IX Severely affected patients develop haemarthroses Inhibitors (factor IX antibodies) less common Recombinant factor IX – 18 hour half life so daily dosing to maintain levels Prophylactic treatment...

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Headache

Headache is a very common problem. The vast majority of headaches, even though they can be disabling for patients, will be benign. Important points in the history Pattern Intermittent Continuous Diurnal variation / time...

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Hearing Loss in Adults

Common causes External meatus blocked by wax Presbyacusis Sensorineural hearing loss Presbyacusis Loss of hair cells on cochlear as increase in age Audiogram; High frequencies lost first, low frequencies stay in normal range, no...

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