Site icon almostadoctor

Memantine

Drugs in medicine

Drugs in medicine

Memantine is an N-methyl-D-aspartate (NMDA) antagonist and is licensed for use in moderate-severe Alzheimer’s disease (AD).

Mechanism of Action

 

Indication and dose

Moderate to severe Alzheimer’s Disease

 

Cautions

Patients who have a history of convulsions

 

Interactions

The interactions listed here are POTENTIALLY SERIOUS which is indicated by a black dot in the BNF. Further details of these interactions can be found in the BNF or Stockleys.

Furthermore, there are other interaction which are not potentially serious, nevertheless they should still be monitored and clinical judgement should be used.

 

Side effects

Common:

Constipation, dizziness, drowsiness, dyspnoea, headache, hypertension

Hepatic Impairment

BNF states that is should be avoided in the severe hepatic impairment.

 

Renal Impairment

 

 

References

BNF 70, Joint Formulary Committee (2015) British National Formulary. 70th Ed., London: British Medical Association and Royal Pharmaceutical Society of Great Britain.

National Institute for Health and Clinical Excellence, NICE technology appraisal guidance [TA217], National Institute for Health and Clinical Excellence, March 2011

 

 

Related Articles

Exit mobile version