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Cromones

Drugs in medicine

Drugs in medicine

Cromones – e.g.Sodium cromoglicate, nedocromil sodium
This is often described as a mast cell stabilizer. It prevents the release of inflammatory mediators (such as histamine) from mast cells.
These drugs have no bronchidilator activity, and thus are of no use in an asthma attack; thus they are preventative. They are usually less effective than inhaled corticosteroids.
Their main use is in mild-to-moderate, antigen induced and exercise induced asthma. They are also used as an inhalant to treat seasonal rhinitis, and as an ophthalmic agent to treat conjunctivitis.

Mechanism

Use

The very first dose will protect against the early phase reaction. Treatment may be required for 1-2 months to provide protection against the late phase reaction

Pharmacokinetics

Unwanted effects

References

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