Overdose – Common Drugs and Antidotes

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Drug Antidote Amitriptyline Sodium Bicarbonate Beta-blockers Glucagon Benzodiazepines Flumazenil Bupivicaine Intralipid Cyanide Hydroxocobalamin / Nitrites (inhaled) Digoxin Digoxin Antibodies Heparin Protamine Hydrofluoric Acid Calcium Iron Desferrioxamine Methanol Ethanol Methaemoglobin Methyline…

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Overdose and Poisoning

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Opiates Naloxone will reverse the effect of opiate overdose, typically in the presence of CNS and respiratory depression. It competitively binds opioid receptors, causing a blockade Usually given IV for…

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Overview of Diuretics

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Managing diuretics It is common for a patient on diuretics to become hypokalaemic. This is dangerous because it predisposes to arrhythmias. It may also precipitate encephalopathy in those with liver…

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Introduction Paracetamol (acetaminophen) is a widely used anti-pyrexic and analgesic, with similar efficacy in these areas to aspirin, however, unlike aspirin and NSAIDs it has virtually no anti-inflammatory properties. It…

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Potassium Sparing Diuretics

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Introduction Potassium sparing diuretics inhibit the reabsorption of sodium (and water) from the distal tubule by antagonising aldosterone. They have only a relatively weak diuretic effect. They reduce potassium excretion…

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Introduction Propofol is a drug widely used for sedation and general anaesthesia. It also gained notoriety for its involvement in the death of Michael Jackson. It usually comes in a…

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Proximal Tubule Diuretics

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Proximal tubule diuretics e.g. acetazolidamide These drugs are carbonic anyhrdrase blockers. Some sodium is reabsorbed in conjunction with hydrogen. This process relies on the carbonic anhydrase to catalyse the reaction…

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Quetiapine is a commonly used atypical antipsychotic medication. Indications include schizophrenia, bipolar disorder, depression, and acute delirium. Mechanism Dopamine, serotonin and adrenergic antagonist Antihistamine Binds very strongly to serotonin (5-HT)…

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Reading a Prescribing Chart – Medicines Management

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Legal Requirements for a prescription Hospital number or address Name of patient Date Name of drug Dose – unless only one dose available for that particular drug Signature Date of…

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Renin Inhibitors

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  Mechanism of action Renin Inhibitors act by > directly inhibit renin! Renin converts angiotensinogen to angiotensin I Renin inhibitors (Aliskiren) competes with angiotensinogen for the active site of the…

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