Alcoholic Hepatitis

Introduction Alcoholic hepatitis is a very common cause of liver injury. It is caused by excessive alcohol intake. Typically there will be steatosis of the liver. In this pathological change, fat globules begin to accumulate in...

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Bilirubin Metabolism and Jaundice

Production of Bilirubin Every haem molecule will produce one molecule of bilirubin. These molecules are found in haemoglobin and myoglobin. Also, cytochrome enzymes will also produce one molecule of bilirubin. The production of bilirubin...

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Causes of Hepatomegaly

Massive = "CRAM" Cancer – primary and secondary Right heart failure Alcoholic liver disease with fatty infiltration Myeloproliferative diseases (ie Chronic myeloid laekaemia, PRubraVera,Essential Throbocythaemia) Moderate = "FAILL"  all of the above plus Fatty...

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Haemochromatosis

Introduction The term haemochromatosis is usually used to describe a group of autosomal recessive disorders of iron metabolism. It is sometime called hereditary haemochromatosis and abbreviated to HHC. The most common mutations are in...

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Hepatorenal Syndrome (HRS)

Hepatorenal syndrome is renal failure secondary to liver disease. It is a life-threatening acute complication of liver failure. It is most commonly seen in alcoholic hepatitis, although can occur in liver failure of any...

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Liver Physiology

Function The two roles of the liver are: Processing of absorbed materials Excretion of unwanted products and secretion of stuff to help with fat digestion Structure The liver is divided into many thousands of...

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