Alcohol and Alcohol Abuse
Alcohol abuse and addiction

Alcohol and Alcohol Abuse

  • Reading time:34 mins read

Introduction Alcohol is the most dangerous addictive drug in the world. It kills around 15 Australians every day. Alcohol abuse is widespread in Western Society, and is a common presenting…

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Alcoholic Hepatitis
Mallory body seen on histology. Mallory bodies are eosinophilic inclusions that have a "rope-like" appearance. Note the highlights body on this image. This file is taken from wikimedia commons and is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.

Alcoholic Hepatitis

  • Reading time:4 mins read

Introduction Alcoholic hepatitis is a very common cause of liver injury. It is caused by excessive alcohol intake. Typically there will be¬†steatosis¬†of the liver. In this pathological change, fat globules…

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Bilirubin Metabolism and Jaundice
Jaundice with scleral icterus. This file is taken from wikimedia commons and is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.

Bilirubin Metabolism and Jaundice

  • Reading time:8 mins read

Production of Bilirubin Every haem molecule will produce one molecule of bilirubin. These molecules are found in haemoglobin and myoglobin. Also, cytochrome enzymes will also produce one molecule of bilirubin.…

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Causes of Hepatomegaly
Image of liver showing hepatomeagaly

Causes of Hepatomegaly

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Hepatomegaly describes an¬†enlarged liver.¬†There are many causes of hepatomegaly, and learning some mnemonics might help you to memorise some of them! Sometimes it is associated with an enlarged spleen -…

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Clinical Consequences of Liver Disease
Cirrhosis of the liver

Clinical Consequences of Liver Disease

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Vitamins A, D, E and K are all stored in the liver, as is vitamin B12. Therefore, in liver damage, storage of these is reduced. Portal circulation Note that there…

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EBV – Epstein Barr Virus

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Introduction Epstein-Barr virus (EBV) is a type of human herpes virus. It is extremely widespread, and is contracted by close person to person contact. It can cause a wide range…

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Haemochromatosis

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Introduction The term haemochromatosis is usually used to describe a group of autosomal recessive disorders of iron metabolism. It is sometime called hereditary haemochromatosis and abbreviated to HHC. The most…

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Hepatorenal Syndrome (HRS)

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Hepatorenal syndrome is renal failure secondary to liver disease. It is a life-threatening acute complication of liver failure. It is most commonly seen in alcoholic hepatitis, although can occur in…

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Liver Physiology

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FunctionThe two roles of the liver are:Processing of absorbed materialsExcretion of unwanted products and secretion of stuff to help with fat digestionStructureThe liver is divided into many thousands of ‘lobules’…

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Viral Hepatitis Overview

  • Reading time:4 mins read

Hepatitis is liver disease characterised by the presence of immune cells within the liver. Viral Hepatitis Many viruses are able to infect the liver, some of these will only affect…

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