Haemophilia A

Haemophilia A

  • Reading time:5 mins read

Introduction Haemophilia A is one of several genetic inherited clotting disorders, the other most common ones being haemophilia B and von Willebrand's disease. It typically presents in neonates and young…

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Haemophilia B (Christmas Disease)

Haemophilia B (Christmas Disease)

  • Reading time:4 mins read

Introduction Haemophilia B is an inherited X-linked recessive clotting disorder, which can cause excessive bleeding. Haemophilia B causes a similar, but generally less severe disease than haemophilia A. Most cases…

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Iron Studies

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Introduction Iron studies are indicated in patients with anaemia, particularly those with microcytic anaemia. They may also be indicated in microcytosis (without anaemia), general lethargy and tiredness and malnutrition. Iron…

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  • Reading time:23 mins read

Introduction Leukaemia is a broad term, applied to a range of blood cell cancers. The leukaemias can be classified as acute or chronic, and sub-classified as myeloid or lymphoid.  Thus, there…

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  • Reading time:20 mins read

Introduction Can be divided into two types; Hodgkin’s and non-Hodgkin’s. Lymphoid leukaemias also exist, and the distinction between these and leukaemia - especially chronic lymphocytic leukaemia - can be difficult.…

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Microcytic anaemias

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Introduction Anaemia is one of the most common presenting complaints to general practice. One of several ways in which anaemias can be classified, is by red cell size. As such,…

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  • Reading time:1 mins read

Marrow fibrosis and splenomegaly, de novo or following transformation of PV or ET Usually >50 years old Abnormal megkaryocytes produced in increased numbers. PDGF and TGFβ are released by megakaryocytes,…

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  • Reading time:10 mins read

Introduction Myeloma is a malignant disease of the plasma cells of the bone marrow.  It is characterised by a proliferation of these plasma cells, and overproduction of an antibody (known…

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Myeloproliferative Diseases

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Clonal proliferation of haematopoietic components in the bone marrow leads to an increase in numbers of one or more lineages of mature blood cells. Myeloproliferative disorders have the potential to…

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Other Coagulation Factor Deficiencies

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Factor XI deficiency: mainly found in Ashkenazi Jews, recessive inheritance. Homozygotes <5% levels of factor XI. Factor XI concentrate given. Factor VII deficiency: autosomal recessive, variable bleeding severity, risk of…

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