• X-linked recessive condition, deficiency of factor IX
  • Severely affected patients develop haemarthroses
  • Inhibitors (factor IX antibodies) less common
  • Recombinant factor IX – 18 hour half life so daily dosing to maintain levels
  • Prophylactic treatment can be given once or twice weekly

Named for the patient in the leading paper on the disease (Mr. Christmas), published in the BMJ Christmas edition 1952

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