Pills and similar preparations

Original article by Tom Leach and Patricia Seddon | Last updated on 28/5/2014
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Combined oral contraceptive (COC) Pill

Contain both oestrogen and progestogen. This method is:
  • Reliable and reversible
  • Can reduce dysmennorrhoae (painful menstruation) and menoorhagia (heavy bleeding)
  • Can reduce PMT (pre-menstrual tension)
  • Reduce the risk of ovarian, endometrial and colon cancer
  • Reduce the risk of PID
  • Reduces acne is some women
  • Reduces risk of fibroids and ovarian cysts
 
They can be divided into three main types:

Monophasic – each pill contains the same amount of progesterone and oestrogen.
Phasic – the concentrations of hormones in each pill varies with the time of the cycle.

  • Both monophasic and phasic pills are in a 21 day supply, with a 7 day break from days to allow breakthrough bleeding. You are still protected from pregnancy during the 7 day period, provided all the other pills were taken correctly.

EveryDay pills – 28 days supply, with 7 days of placebo pills in days 22-28. The pills must be taken in the right order.

They are available in varying strengths. The lowest dose that produces the desired effects should be used. Typically the oestrogen component is a variant of oestrogen known as ethinylestradiaol – and typically doses are 20 – 40 micrograms.
 

Summary

COMBINED PILL
EFFECTIVENESS
>99% when taken correctly.
PREPERATIONS
Microgynon (Ethinylestradiol and levonorgestrel)
HOW IT WORKS
Contains both oestrogen and progesterone.
Stops ovulation
Thickens cervical mucus preventing passage of perm, thins lining of uterus preventing implantation.
ADVANTAGES
Very effective when taken correctly
reduces bleeding, pain and PMT.
Reduced hirtuism and acne
Reduces risk endometrial and ovarian ca. Possibly [controversial] inc risk breast ca.
Fertility quick to return..
DISADVANTAGES
Progestrogens cause :Headache, Breast tenderness, breakthrough bleeding
Oestrogens cause: Nausea and vomiting, Fluid retention, Mood changes
Inc risk of cardiovascular disease (Thromboembolism)
CI
Absolute CI’s
Migraine – with typical focal aura, or severe migraine >72hrs,
Personal history venous or arterial thrombosis,
Heart disease assoc c DVT or PE, Stroke
Liver disease
BP>160/95
Age >50, or age >35 and smoker
Smoker >40/day
 
Avoid if two or more of following:
Fx venous thromboembolism / arterial disease, obesity, long-term immobilization, varicose veins.
DM, hypertension, smoking, >35yrs, obesity, migraine
 
NB: epilepsy drugs interfere with pill so need higher dose in epileptics.
COMMENTS
Take 21 pills and one week off (some preparations have placebo 7 days, in a 28 day packet)
Start first course on 1st day period. If starting after day 4 of period, or if miss pill >24hr time allocation must use barrier contraception for 7days.

More Info

Efficacy

  • Quoted as >99% effective
  • Described as: if taken correctly, then during the course of 1 year, <1% of women taking the COC pill will become pregnant
 

Mechanism

  • Prevents ovulation
  • Thickens cervical mucous
  • Alters uterine lining to prevent implantation
 

Side effects

Oestrogen increases the risk of cardiovascular disease (notably thromboembolus). It also causes:

  • Nausea (progesterone does not)

Progestogens can cause: headache, depression, acne, breakthrough bleeding and breast symptoms. Many of these resolve themselves after several weeks/months of treatment, and can be solved if a different progestrogen is used, however, some progestogens are also associated with increased thromboembolic risk

  • Thromboembolic risk – is increased in those taking the COC, particularly during the first year of use, but the risk is small, and smaller than in pregnancy (when the risk is 60 per 100 000).
  • In all patients the risk of thromboembolism increases with age.
  • There is also an increased risk of DVT when travelling (>5 hour flights) and women should be informed of and encouraged to perform inflight exercises.
  • Breakthrough bleeding is particularly common in the first few months, but usually resolves.
  • The risk of weight gain on the COC is unproven
 

Missing a pill

The general rule is that the combined pill can be taken within 12 hours of the usual time of administration, and still be effective.
If a pill is missed, the woman should take it as soon as she remembers, and then continue taking the rest of the pills at their normal time; even if this means taking two at once
A ‘missed pill’ is one that is >24 hours after she should have taken it

  • Just missing one pill is not a problem, nor is starting a new pack one day late, as long as the missed pill is taken with the next one.

The greatest risk of pregnancy if a pill is missed is at the beginning and end of a cycle.
If 2 pills are missed (i.e. >24 after time should have been taken) then there is a risk of pregnancyespecially if the pill was missed in the first 7 days of the cycle.

  • If the patient has had sexual contact during the missed period, emergency contraception is recommended.
  • If not, then the advice is to continue taking the rest of the pills as normal, and use an additional method of contraception (e.g. condoms) for 7 days. If this 7 days includes the 7 days ‘break’ at the end of the cycle, the next packet should be started immediately, and the ‘break’ omitted.
  • The patient should not take the missed pills if >2 pills were missed.
 

Vomiting and diarrhoea

  • If vomiting occurs within 2 hours of taking a pill, another pill should be taken
  • If there is vomiting or diarrhoea for >24 hours, then this should be treated the same as a missed pill – i.e: the pills should be taken as normal, but additional contraception (e.g. condoms) should be used for 7 days after the end of the period of illness. If this 7 days runs into the last 7 days of the cycle, the next packet of pills should be started straight away, and the ‘break’ omitted.
 

Drug interactions

Several drugs are known to reduce the effectiveness of the pill )’enzyme inducing drugs’). You should always check other medications the patient is on (in the BNF) before prescribing a contraceptive, and seek expert advice. Some common examples of interactions are given below:
  • Carbamazepine
  • Pheytoin
  • Phenobarbital
  • St John’s Wort
  • Rifabutin
  • Rifampicin
In women taking these drugs it is advisable to seek alternative methods of contraception

When taking a course of antibioticsit is advisable to use condoms during the course and for 7 days afterwards.

  • If you pass day 21 of the packet, then start a new packet immediately, even for everyday pills.
  • If the course of AB’s lasts longer than 2 weeks, alternative methods of contraception should be sought
 

Surgery

It is advisable to discontinue all oestrogen-containing contraceptive 4 weeks before major surgery to reduce the thromboembolus risk. You can safely resume them at the first menses > 2 weeks after surgery.
 

Contraindications / reasons to stop taking immediately

 

Cautions

If two or more of the following are present, alternative contraception should be recommended
  • Age over 35
  • Obesity
    • BMI >39
  • Migraine (without aura)
  • BP >140/90
  • Smoker <40/day
  • FH of arterial disease
  • Diabetes <20y
 

Prescribing

Women with RF’s for cardiovascular disease should be prescribed the lowest does of oestrogen (20micrograms ethinylestradiol), or should be prescribed an alternative if >2 RF’s are present
Women >50 should not use the COC as better alternatives are available, and the cardiovascular disease risk is high
Inform patient to seek help immediately if:

Missing the withdrawal bleed

  • It is ok to use two packets one after the other (i.e. start the second packet on day 22). This can be done for up to 3 months in a row. Tell the patient the lining of the womb does not keep on growing during this time!
  • Remember to tell patients on the everyday pill to start the new packed on day 22

Length of prescription

  • Normally when first prescribed, given for 3 months. After this time, BP will be checked, and if no problems or additional RF’s, then will be prescribed for 1 year at a time.
 

Commencing treatment

No Previous contraception

  • Start on day 1 of cycle, OR
  • If starting after day 4 of cycle, use extra method (e.g. condom) for first 7 days

Changing from progesterone only pill

After child birth

  • If not breastfeeding, start 3 weeks after birth (otherwise, ↑risk of thrombosis)
  • If started after 3 weeks, other methods of contraception (e.g. condoms) required for first 7 days.
  • DO NOT USE IN BREASTFEEDING – alters lactation

After miscarriage / abortion

  • If less than 24 weeks, start pills straight away. If >24 weeks, seek advice
 

Examples

  • Microgynon
  • Qlaira
 

Alternative preparations

Skin patch

  • May have a higher risk of thromboembolism than the oral preparation
  • Treatment consists of three patches. First patch applied on day 1 of cycle, second on day 8, and third on day 15. Remove old patch each time, and remove third patch on day 22, and have a week with no patch.
  • If the first patch is applied on any day other that day 1, another method of contraception (e.g. condoms) need to be used for 7 days
  • Withdrawal bleeding occurs during patch-free week

 

Vaginal contraceptive ring

  • A small rubber ring that can be inserted into the vagina by the patient, and then sits around the cervix. Stays in place for 3 weeks. Remove after 3 weeks, and have 1 week without ring present (similar to pill and patch)
  • Withdrawal bleeding occurs during ring-free week
 

Progesterone Only Pill (POP)

  • Generally used when COC is contra-indicated
  • Not as effective as COC, although still >99% effective
  • Often used in those on COC before / during / after surgery
 

Summary

PROGESTERGONE ONLY PILL
EFFECTIVENESS
99% effective when used correctly
PREPERATIONS
Cerazette, Mini Pill
HOW IT WORKS
Thickens cervical mucus,
thins lining of womb,
Higher dose pop ie. cerazette also inhibits ovulation
ADVANTAGES
Can be taken in those with CI to COC ie. breastfeeding, older women, cardiovascular risk, DM
>35yrs who smoke
normal fertility resumed immediately
DISADVANTAGES
Dysfunctional bleeding ie. irregualar, IMB. In many cases, bleeding is reduced or event absent
Breast tenderness, acne, weight change, headaches
Increased risk of ovarian cysts
CI
Previous cysts or ectopic – may have slight inc risk ectopic if get pregnant
COMMENTS
Take continuously for 28days at same time.
Mini Pill - If miss pill >3hrs must take barrier contraception for 7d
Cerazette – allows 12 hour window
Advantages over POP
  • Can use when breastfeeding
  • Not age restricted
  • Can help to reduce painful periods

Mechanism

  • Thickens cervical mucus
  • Alters lining of the uterus, making it difficult for implantation to take place
  • Some (Cerazette) also prevent ovulation – this probably means cerazette is more effective than other POP’s but there is no conclusive evidence yet
 

Side effects

  • Far fewer serious side effects than COC
  • Periods may be irregular / light / may stop completely. In some cases, they can become more heavy
  • Temporary side effects in first few months of treatment:
  • Ovarian cysts – small risk, may cause pelvic pain, but usually resolve spontaneously.
  • Increased risk of ectopic pregnancy in the unlikely event of pregnancy occurring
 

Advantages of POP over COC

  • Can use when breast feeding
  • Useful when COC is contra-indicated
  • Can be used at any age:
    • Particularly useful in smokers over 35, in which COC is CI’d
    • Can reduce premenstrual symptoms and painful periods
 

Prescribing

Time window for admission during which the pill is effective is small (3 hours). However, the pill Cerazette allows a 12 hour window, similar to COC. Sometimes the regular (3hr window) POP is called the Mini Pill.
 

Starting treatment

Start on the first day of the cycle. If started within the first 5 days, protection is immediate
If started after day 5, use condoms or another contraception for 2 days

  • Those with a short menstrual cycle (<23 days) may not be protect if they start on day 4 or 5, as ovulation may occur early. Advise condoms for 2 days after commencing POP

After miscarriage / abortion

  • If <24 weeks, start straight away
  • If >24 weeks seek advice

After Pregnancy

Does not interfere with lactation, or increase the risk of thromboembolic event, and thus can be start straight after pregnancy

A small amount of progesterone does enter the breast milk, but this does not cause any adverse effects in the child

If started after 21 days after birth, use an additional method of contraception for 2 days 

 

Missed pills

Take the missed pill and the next pill s soon as you remember. If the missed pill was >3 hours late (12 hours for cerazette), then you are not protected, and condoms should be used for 2 days.

Vomiting and diarrhoea

  • If this occurs within two hours of taking the pill, use condoms or another method of contraception for 2 days after
 

Interactions

Fewer than COC – e.g. antibiotics are generally not a problem, however, any liver enzyme inducing drugs may still interact.
  • Additional contraception (e.g. condoms) should be used during treatment with the enzyme inducing drug, and for 4 weeks after