•  Adulthood (20-40)
  •  Coeliac’s disease (transglutaminase)
  •  M:F 2:1


  • Deposition of  IgA in papillary dermis causing an immunological cascade
  • Is an immunologic response to chronic stimulation of the gut mucosa. IgA react to gluten-tissue transglutaminase (t-TG) in the gut, and epidermal transglutaminase (e-TG).
  • Genetic predisposition with HLA expression (10% have affected relative)

Signs & Symptoms

  • Suicidally itchy’ blisters and papules. Intensely pruritic
  • Often few blisters as most are scratched and therefore appear as papules
  • Intermittent cutaneous lesions mainly affecting the buttocks, knees and elbows
  • Rraely any bowel symptoms of coeliac’s disease
Dermatitis Herpetiformis rash on abdomen

Dermatitis Herpetiformis rash on abdomen


Gluten free diet for life to control symptoms and reduce risk of small bowel lymphoma
If unsuccessful
  • Dapsone (antibacterial)
  • Sulphapyridine (sulphonamide ABx)


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