Acne Vulgaris

Introduction Acne vulgaris (often shortened to “Acne”) disorder of the Pilosebaceous Follicles Incredibly common Almost universal in the second decade of life Also affects adults Associated with psychological problems, including depression, anxiety and social...

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Bullous Pemphigoid

Aetiology Elderly (>65yrs) Vaccinations (in children with  condition affecting face, palms and soles)  NSAIDs, furosemide, antibiotics UV radiation / x-rays   Pathophysiology Autoimmune, subepidermal blistering due to IgG  autoantibodies for the basement membrane proteins...

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Bullous Pemphigus

Aetiology  Middle aged (40-60yrs)  High prevalence in Jewish regions  Lifelong condition   Pathophysiology Autoimmune, epidermal blistering due to IgG  autoantibodies for keratinocyte surfaces (desmoglein) Often mucosal involvement (>90%) Potentially life threatening (rare) if it...

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Burns

Assessing burn depth Superficial – epidermis (erythema) only. Can be differentiated from partial thickness by rubbing the skin. If the epidermis moves around, sliding over the deeper layers, this is a partial thickness burn...

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Cellulitis

Introduction Cellulitis is caused by bacterial infection of the dermis layer of the skin and the deeper subcutaneous tissues. Often the infection is due to a break or puncture to the skin which allows...

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Dermatitis Herpetiformis

Aetiology  Adulthood (20-40)  Coeliac’s disease (transglutaminase)  M:F 2:1 Pathophysiology Deposition of  IgA in papillary dermis causing an immunological cascade Is an immunologic response to chronic stimulation of the gut mucosa. IgA react to gluten-tissue...

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Eczema (Dermatitis)

Eczema (aka Dermatitis) presents as a poorly demarcated, itchy rash. There are several causes. By far the most common is atopic eczema, but irritants and venous stasis can also cause the condition. Atopic Eczema...

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Henoch Schonlein Purpura (HSP)

Introduction Henoch-Schonlein Purpura (HSP) is a vasculitis that most commonly occurs in children. It is the most common vasculitis of childhood, and typically present in children aged between 2-8. in 50% of cases there...

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Hidradenitis suppurativa

Introduction Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition, which manifests in the intertriginous areas (part of the skin where two opposing surface touch – e.g. armpits, groin, under breasts, perineum, buttocks and...

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Psoriasis

Pathology Keratinocyte hyperproliferation: differentiation, or ‘skin cell going from basal layer to horny layer’, reduced from 4 weeks to 4 days [approximately!] Histopathological features: Parakeratosis: retained nuclei Acanthosis: thick epidermis Absent granular layer Lengthened...

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