Goodpasture’s syndrome (anti-GBM antibody disease)
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This is a rare, genetic, autoimmune condition characterised by a combination of glomerulonephritis with alveolar hemorrhage in the presence of circulating anti-glomerular basement membrane (GBM) antibodies.  Circulating anti-GBM antibodies bind to basement membranes in the kidneys and lungs, fix complement and trigger a cell-mediated inflammatory response, causing glomerulonephritis and pulmonary capillaritis.
Specific predisposing factors include the following:
  • Association with HLA-DR2
  • Exposure to organic solvents or hydrocarbons
  • Smoking
  • Infection, e.g. influenza A2
  • Cocaine inhalation
  • Exposure to metal dusts
Diagnosis of Goodpasture’s requires presence of anti-GBM antibodies in serum, but confirming a diagnosis lies with performing a renal biopsy when glomerulonephritis is present.

 

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Dr Tom Leach

Dr Tom Leach MBChB DCH EMCert(ACEM) currently works as a GP Registrar and an Emergency Department CMO in Australia. He is also a Clinical Associate Lecturer at the Australian National University. After graduating from his medical degree at the University of Manchester in 2011, Tom completed his Foundation Training at Bolton Royal Hospital, before moving to Australia in 2013. He started almostadoctor whilst a third year medical student in 2009. Read full bio

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