Causes of Splenomegaly
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Splenomegaly is a term that refers to an abnormally enlarged spleen. There are many causes of splenomegaly, the most common of which can be summarised with the mnemonic CHICAGO (below).
Splenomegaly may also be associated with an enlarged liver (hepatomegaly) – as many of the causes are similar – in which case it is referred to as hepatosplenomegaly. 
  • C – Cancer
  • H – Haematological malignancies – anaemia, leukaemia, lymphoma,
  • I – Infection (CMV, HEP, HIV, TB, parasitic (malaria)). EBV is the most common community acquired
    • Inflammation – sarcoid, amyloid
  • C – Congestion; portal hypertension
  • A – Autoimmune(RA, SLE)
  • G – Glycogen storage disorders
  • O – Other – amyloidosis, sarcoidosis

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Dr Tom Leach

Dr Tom Leach MBChB DCH EMCert(ACEM) FRACGP currently works as a GP and an Emergency Department CMO in Australia. He is also a Clinical Associate Lecturer at the Australian National University, and is studying for a Masters of Sports Medicine at the University of Queensland. After graduating from his medical degree at the University of Manchester in 2011, Tom completed his Foundation Training at Bolton Royal Hospital, before moving to Australia in 2013. He started almostadoctor whilst a third year medical student in 2009. Read full bio

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