Incubation period; varies according to site of injury, shorter (approx. 1 week in severe disease)
Spores of c.tetani live in faeces, soil and dustàcan be introduced by small break in skin/via mucosa.
**Tetanus is only infectious vaccine preventable disease that isnt contagious
Now almost exclusively affects those not vaccinated
more common in
Hot, damp climates.
Those who work in agriculture (manure).
Heroin users (spores can be found in contaminated heroin)
WHO estimates 59,000 newborns worldwide died in 2008 as a result of neonatal tetanus.
Spores germinate in anaerobic conditions at wound site and produce neurotoxinsàtoxins travel up peripheral nerves and cleaves the protein that allows fusion oif the synaptic vesicle with the membraneàprevents transmitter release.
Primarily affects inhibitory glycine or GABAàleads to less inhibition(relaxation)àincreased firingàcontraction skeletal musle.
Dr Tom Leach currently works as a GP Registrar and an Emergency Department CMO in Australia. He is also a Clinical Associate Lecturer at the Australian National University. After graduating from his medical degree at the University of Manchester in 2011, Tom completed his Foundation Training at Bolton Royal Hospital, before moving to Australia in 2013. He started almostadoctor whilst a third year medical student in 2009.
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