Main causes of chronic renal failure:
- Metabolism of urea – urea comes from CO2 and NH2. NH2 comes from protein. Thus, to have a high urea, you either have to have renal failure, or excessive protein load. The creatinine then tells you which it is; ↑↑creatinine and ↑↑urea will be renal failure, ↑↑urea and ↔creatinine will just be patients with a high protein load.
- What causes a high protein load? – think of situations where the body utilises protein instead of carbohydrate as its main energy source. i.e. starvation, (usually alcoholism), or extreme exercise (athletes). Also, there are other situations where there are excessive amounts of protein in the blood: haematemesis, and liver failure.