
Contents
Introduction
The contraceptive injection is a common form of progesterone only contraception given to women. Injections are typically given every 3 months. Hormonal injections and generally considered >99% effective for contraception, but provide no protection against STIs.
There can be a slightly erratic return to normal period after the medication is ceased. There is also a risk of weight gain compared to some other methods of contraception.
There are two brands available in the UK:
Depo-Provera – administered every 12 weeks
- Injection of choice
- Aka Medroxyprogesterone acetate
Noristerat – administered every 8 weeks
- Depo-provera is more effective than Noristerat
- Usually only offered as short-term treatment – e.g. for women waiting for sterilisation
Summary
CONTRACEPTION | INJECTABLE PROGESTERONE |
EFFECTIVENESS | > 99% effective |
PREPARATIONS | Depot (every 12 wks) Noristerat (every 8 wks) |
HOW IT WORKS | slow release of progesterone into body – thinning endometrium, preventing ovulation and thickening cervical mucus |
ADVANTAGES | No oestrogen content Reduces PID Can use in Breastfeeding and epileptics |
DISADVANTAGES | May cause irregular bleeding – amenorrhoea, irregular , longer Fertility may take time to return to normal (~10m) Weight gain ~ 3kg in 1st yr |
Contra-indications | Abnormal undiagnosed vaginal bleeding, severe cardiac disease, acute liver disease |
Efficacy
- Quoted as >99% effective
- Described as: if taken correctly, then during the course of 1 year, <1% of women using the injection will become pregnant
Mechanism
Prevent ovulation – and may stop periods
- Other methods of progesterone only contraception will often make periods lighter, and may prevent them in some women. However, progestogen injection will be more likely to prevent ovulation and regular menstrual bleeding in a higher proportion of women.
- This is the main benefit of this treatment over other options
- Some women may get heavier or irregular periods
Thickens cervical mucus
Alters lining of the uterus, making it difficult for implantation to take place
Cautions and contraindications
Should not be first line in women <18 or >45 due to risk of reduction in bone density
- In women <18 can alter the formation of new bone, as bones are still developing
- In women over 45 can increase the rate of bone density reduction
- The reduction in bone density is greatest in the first 2-3 years of use, then stabilises.
Should be avoided when other RF’s for osteoporosis are present
- Low oestrogen due to amenorrhoea for >6 months – e.g. due to extreme dieting, exercise or eating disorder
- Smoker
- Heavy drinker
- Long-term steroid use
- FH of osteoporosis (1st degree relatives)
Side effects
- Bleeding may be heavier for the first 3-4 months, but will usually settle down, and most women ultimately do not have periods
- Mood swings
- Reduction in bone density / increased risk of osteoporosis in later life
- Weight gain – typically 2-3Kg per year
Benefits over oral POP
More likely to inhibit ovulation, thus:
- Less likelyhood of periods
- Recued risk of ovarian cysts and ectopic pregnancy
- Also, no interaction with non-enzyme inducing antibacterials
Drug interactions
Enzyme-inducing drugs
- E.g. St John’s Wort
- TB, epilepsy and HIV medications
- If the patient also takes any of these, it is recommended to use additional contraception (e.g. condoms) for the duration of the treatment and for 4 weeks after
Prescribing and administration
Given IM, usually into the gluteal muscles. Depo-provera may be given in the leg or arm
- Noristat is a more viscous solution and may be more painful during administration
If there is any chance of pregnancy, the patient must have a pregnancy test before commencing treatment.
- Administration during pregnancy can masculinise the fetus
Treatment should be commenced within 5 days of the start of the cycle
- If started at any other day in the cycle, another method of contraception (e.g. condoms) should be used for the first 7 days.
After pregnancy
- o Usually started 6 weeks after pregnancy. This reduces the risk of heavy / irregular periods.
- Can be given after 21 days on request
- If given at 6 weeks, then an alternative form of contraception (e.g. condoms) should be used between 21 days and 6 weeks
- Pregnancy cannot occur in the first 21 days after the birth of a previous child
After miscarriage / abortion
- Treatment can be started immediately, and will be immediately effective
General advice
- Breast-feeding is not affected
- Missing an injection
- You can be up to two weeks late for the next appointment, and still be fully ptorected:
- i.e. 10 weeks for Noristerat
- 14 weeks for Depo-Provera
- Duration of treatment – Providing there are no contra-indications, or RF’s for osteoporosis, treatment can be continued until menopause
- topping treatment
- Fertility can take several months to return after treatment is stopped.
- Important to warn patients they can get pregnant after cessation of treatment but before their first normal period.
References
- Murtagh’s General Practice. 6th Ed. (2015) John Murtagh, Jill Rosenblatt
- Oxford Handbook of General Practice. 3rd Ed. (2010) Simon, C., Everitt, H., van Drop, F.
- Beers, MH., Porter RS., Jones, TV., Kaplan JL., Berkwits, M. The Merck Manual of Diagnosis and Therapy